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Ionis Pharmaceuticals - 34 Year Stock Price History | IONS

Historical daily share price chart and data for Ionis Pharmaceuticals since 1991 adjusted for splits and dividends. The latest closing stock price for Ionis Pharmaceuticals as of May 28, 2025 is 32.43.
  • The all-time high Ionis Pharmaceuticals stock closing price was 86.14 on April 08, 2019.
  • The Ionis Pharmaceuticals 52-week high stock price is 52.34, which is 61.4% above the current share price.
  • The Ionis Pharmaceuticals 52-week low stock price is 23.95, which is 26.1% below the current share price.
  • The average Ionis Pharmaceuticals stock price for the last 52 weeks is 37.88.
For more information on how our historical price data is adjusted see the Stock Price Adjustment Guide.
  
Ionis Pharmaceuticals Historical Annual Stock Price Data
Year Average Stock Price Year Open Year High Year Low Year Close Annual % Change
2025 31.8920 34.6900 34.9700 25.5100 32.4300 -7.24%
2024 43.1008 52.8700 53.5500 33.7300 34.9600 -30.90%
2023 41.3095 37.5800 51.6300 33.5800 50.5900 33.94%
2022 38.7002 32.6000 48.6600 29.8800 37.7700 24.12%
2021 40.8556 56.7800 63.7800 25.6100 30.4300 -46.18%
2020 54.1692 60.8900 63.4000 41.6000 56.5400 -6.41%
2019 64.9707 53.7700 86.1400 52.9200 60.4100 11.75%
2018 48.2373 49.2500 59.5400 40.5300 54.0600 7.48%
2017 49.6931 47.3400 64.3900 37.9100 50.3000 5.16%
2016 35.8627 61.6800 61.6800 20.6200 47.8300 -22.77%
2015 59.1678 61.5700 77.0800 38.0400 61.9300 0.31%
2014 41.1384 39.8700 65.0900 22.9800 61.7400 54.97%
2013 25.5855 10.8200 41.6800 10.4900 39.8400 281.61%
2012 10.2666 7.2500 15.4100 7.0900 10.4400 44.80%
2011 8.2683 10.2900 10.3500 6.4700 7.2100 -28.75%
2010 9.6054 11.2700 11.7600 7.7800 10.1200 -8.91%
2009 14.2888 14.4700 18.7000 9.9400 11.1100 -21.65%
2008 14.7687 15.3800 19.0800 10.3700 14.1800 -9.97%
2007 12.1630 10.9300 17.7000 8.3700 15.7500 41.64%
2006 7.7520 5.2500 12.4900 5.1000 11.1200 112.21%
2005 4.4809 5.8000 5.8000 2.8000 5.2400 -11.19%
2004 6.3211 6.8100 9.5000 4.2700 5.9000 -9.23%
2003 5.5755 6.8400 8.0500 2.8000 6.5000 -1.37%
2002 11.4563 21.0500 21.2300 6.1900 6.5900 -70.30%
2001 14.2338 9.6250 26.6500 7.9375 22.1900 108.85%
2000 11.8580 5.8188 33.8125 5.8188 10.6250 71.64%
1999 10.7581 12.3329 15.6513 4.9832 6.1902 -48.11%
1998 11.6561 11.6413 14.4652 6.5122 11.9294 5.08%
1997 14.4116 16.5975 17.8653 10.6039 11.3531 -31.60%
1996 14.2324 12.1023 21.7842 9.6819 16.5975 37.14%
1995 9.0421 3.4578 13.8312 3.4578 12.1023 228.13%
1994 5.4607 6.5698 7.7224 3.1120 3.6883 -40.74%
1993 6.1197 8.9903 10.1429 5.0715 6.2241 -30.77%
1992 8.9899 12.2176 15.2144 4.8409 8.9903 -29.09%
Sector Industry Market Cap Revenue
Medical Medical - Drug Manufacturing $5.303B $0.705B
Ionis Pharmaceuticals discovers/develops RNA-targeted therapeutics using its proprietary antisense oligonucleotide technology. Its antisense medicines have been developed/are being developed to treat neurological, cardiovascular and specialty rare diseases.
Stock Name Country Market Cap PE Ratio
Chugai Pharmaceutical (CHGCY) Japan $87.311B 32.75
Zoetis (ZTS) United States $74.020B 27.62
Daiichi Sankyo, - (DSNKY) Japan $51.315B 26.11
Takeda Pharmaceutical (TAK) Japan $46.678B 9.28
Sandoz Group AG (SDZNY) Switzerland $21.655B 0.00
Summit Therapeutics (SMMT) United States $19.042B 0.00
Merck (MKKGY) Germany $17.125B 12.55
United Therapeutics (UTHR) United States $14.201B 12.56
Shionogi (SGIOY) Japan $14.121B 14.15
Neurocrine Biosciences (NBIX) United States $12.137B 41.57
IPSEN (IPSEY) France $9.821B 0.00
Orion OYJ (ORINY) Finland $9.323B 25.21
Corcept Therapeutics (CORT) United States $8.145B 66.22
Stevanato Group S.p.A (STVN) Italy $6.917B 42.30
Hikma Pharmaceuticals Plc (HKMPF) United Kingdom $6.153B 0.00
Madrigal Pharmaceuticals (MDGL) United States $6.030B 0.00
Grifols, S.A (GRFS) Spain $5.659B 0.00
Ono Pharmaceutical (OPHLF) Japan $4.875B 14.83
Soleno Therapeutics (SLNO) United States $3.843B 0.00
Catalyst Pharmaceuticals (CPRX) United States $3.030B 10.61
Hypermarcas (HYPMY) Brazil $2.873B 18.90
Crinetics Pharmaceuticals (CRNX) United States $2.762B 0.00
AMNEAL PHARMACEUTICALS, INC (AMRX) United States $2.285B 12.36
BioCryst Pharmaceuticals (BCRX) United States $2.258B 0.00
NewAmsterdam Pharma (NAMS) Netherlands $1.910B 0.00
Recursion Pharmaceuticals (RXRX) United States $1.785B 0.00
Centessa Pharmaceuticals (CNTA) United Kingdom $1.705B 0.00
Indivior (INDV) United States $1.630B 6.92
Evotec AG (EVO) Germany $1.518B 0.00
ARS Pharmaceuticals (SPRY) United States $1.436B 0.00
Guardian Pharmacy Services (GRDN) United States $1.401B 0.00
Dyne Therapeutics (DYN) United States $1.330B 0.00
Ocular Therapeutix (OCUL) United States $1.106B 0.00
Aurinia Pharmaceuticals Inc (AUPH) Canada $1.101B 22.03
Harrow (HROW) United States $0.966B 0.00
Ardelyx (ARDX) United States $0.950B 0.00
Collegium Pharmaceutical (COLL) United States $0.947B 5.11
Avadel Pharmaceuticals (AVDL) Ireland $0.876B 0.00
Enliven Therapeutics (ELVN) United States $0.785B 0.00
Cronos Group (CRON) Canada $0.771B 0.00
Akebia Therapeutics (AKBA) United States $0.767B 0.00
Xeris Biopharma Holdings (XERS) United States $0.755B 0.00
AleAnna (ANNA) United States $0.675B 0.00
Elite Pharmaceuticals (ELTP) United States $0.568B 0.00
USANA Health Sciences (USNA) United States $0.566B 12.30
KalVista Pharmaceuticals (KALV) United States $0.558B 0.00
Xencor (XNCR) United States $0.552B 0.00
Regulus Therapeutics (RGLS) United States $0.548B 0.00
Bioventus (BVS) United States $0.536B 13.60
Relay Therapeutics (RLAY) United States $0.489B 0.00
Theravance Biopharma (TBPH) Cayman Islands $0.464B 0.00
Zevra Therapeutics (ZVRA) United States $0.462B 0.00
Altimmune (ALT) United States $0.447B 0.00
Siga Technologies (SIGA) United States $0.434B 9.07
Oruka Therapeutics (ORKA) United States $0.428B 0.00
Amylyx Pharmaceuticals (AMLX) United States $0.421B 0.00
CytoDyn (CYDY) United States $0.406B 0.00
Tourmaline Bio (TRML) United States $0.398B 0.00
Verve Therapeutics (VERV) United States $0.382B 0.00
Organogenesis (ORGO) United States $0.377B 0.00
Rigel Pharmaceuticals (RIGL) United States $0.351B 9.48
Savara (SVRA) United States $0.335B 0.00
Heron Therapeutics (HRTX) United States $0.288B 0.00
Nature's Sunshine Products (NATR) United States $0.272B 25.14
Tonix Pharmaceuticals Holding (TNXP) United States $0.271B 0.00
Aquestive Therapeutics (AQST) United States $0.253B 0.00
MediWound (MDWD) Israel $0.230B 0.00
ProKidney (PROK) United States $0.214B 0.00
Journey Medical (DERM) United States $0.181B 0.00
Wellgistics Health (WGRX) United States $0.180B 0.00
Nanobiotix S.A (NBTX) France $0.180B 0.00
Esperion Therapeutics (ESPR) United States $0.163B 0.00
OmniAb (OABI) United States $0.162B 0.00
Avita Medical (RCEL) United States $0.160B 0.00
Profound Medical (PROF) Canada $0.159B 0.00
4D Molecular Therapeutics (FDMT) United States $0.158B 0.00
Aclaris Therapeutics (ACRS) United States $0.138B 0.00
Liminatus Pharma (LIMN) $0.132B 0.00
Aldeyra Therapeutics (ALDX) United States $0.132B 0.00
Inhibikase Therapeutics (IKT) United States $0.132B 0.00
Nektar Therapeutics (NKTR) United States $0.126B 0.00
Enanta Pharmaceuticals (ENTA) United States $0.124B 0.00
Protara Therapeutics (TARA) United States $0.122B 0.00
Innate Pharma SA (IPHYF) France $0.122B 0.00
Lyell Immunopharma (LYEL) United States $0.121B 0.00
Korro Bio (KRRO) United States $0.120B 0.00
Larimar Therapeutics (LRMR) United States $0.117B 0.00
Achieve Life Sciences (ACHV) Canada $0.110B 0.00
VAXART, INC (VXRT) United States $0.105B 0.00
Cassava Sciences (SAVA) United States $0.103B 0.00
Ironwood Pharmaceuticals (IRWD) United States $0.101B 0.00
OptiNose (OPTN) United States $0.097B 0.00
Cardiol Therapeutics (CRDL) Canada $0.096B 0.00
Fractyl Health (GUTS) United States $0.096B 0.00
Corbus Pharmaceuticals Holdings (CRBP) United States $0.090B 0.00
Lexeo Therapeutics (LXEO) United States $0.090B 0.00
Inotiv (NOTV) United States $0.088B 0.00
Arch Biopartners (ACHFF) Canada $0.084B 0.00
Galectin Therapeutics (GALT) United States $0.083B 0.00
Champions Oncology (CSBR) United States $0.083B 13.61
Cumberland Pharmaceuticals (CPIX) United States $0.080B 59.33
Pyxis Oncology (PYXS) United States $0.077B 0.00
ESSA Pharma (EPIX) Canada $0.071B 0.00
Unicycive Therapeutics (UNCY) United States $0.071B 0.00
Dominari Holdings (DOMH) United States $0.069B 0.00
Vivani Medical (VANI) United States $0.068B 0.00
Nutriband (NTRB) United States $0.067B 0.00
Surrozen (SRZN) United States $0.066B 0.00
Assertio Holdings (ASRT) United States $0.065B 0.00
Telomir Pharmaceuticals (TELO) United States $0.063B 0.00
Metagenomi (MGX) United States $0.062B 0.00
Context Therapeutics (CNTX) United States $0.061B 0.00
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Verrica Pharmaceuticals (VRCA) United States $0.053B 0.00
Gain Therapeutics (GANX) United States $0.052B 0.00
Reviva Pharmaceuticals Holdings (RVPH) United States $0.051B 0.00
Century Therapeutics (IPSC) United States $0.048B 0.00
PMV Pharmaceuticals (PMVP) United States $0.047B 0.00
Mural Oncology (MURA) Ireland $0.045B 0.00
Prelude Therapeutics (PRLD) United States $0.045B 0.00
NRx Pharmaceuticals (NRXP) United States $0.045B 0.00
Karyopharm Therapeutics (KPTI) United States $0.039B 0.00
Avalo Therapeutics (AVTX) United States $0.039B 0.00
Iterum Therapeutics (ITRM) Ireland $0.038B 0.00
ElectroCore (ECOR) United States $0.036B 0.00
Acrivon Therapeutics (ACRV) United States $0.034B 0.00
FibroGen (FGEN) United States $0.032B 0.00
Rafael Holdings (RFL) United States $0.032B 0.00
SCYNEXIS (SCYX) United States $0.028B 0.00
PolyPid (PYPD) Israel $0.026B 0.00
China SXT Pharmaceuticals (SXTC) China $0.024B 0.00
Enlivex Therapeutics (ENLV) Israel $0.024B 0.00
CASI Pharmaceuticals (CASI) China $0.023B 0.00
Tempest Therapeutics (TPST) United States $0.023B 0.00
Relmada Therapeutics (RLMD) United States $0.022B 0.00
Jupiter Neurosciences (JUNS) United States $0.021B 0.00
Natural Alternatives (NAII) United States $0.020B 0.00
BioVie (BIVI) United States $0.019B 0.00
Lipocine (LPCN) United States $0.019B 0.00
Mannatech (MTEX) United States $0.018B 0.00
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DURECT (DRRX) United States $0.016B 0.00
SHINECO (SISI) China $0.015B 0.00
VYNE Therapeutics (VYNE) United States $0.015B 0.00
ProPhase Labs (PRPH) United States $0.015B 0.00
Ernexa Therapeutics (ERNA) United States $0.015B 0.00
GlycoMimetics (GLYC) United States $0.015B 0.00
MEI Pharma (MEIP) United States $0.014B 0.00
Cosmos Health (COSM) United States $0.013B 0.00
Vivos Therapeutics (VVOS) United States $0.013B 0.00
MARKER THERAPEUTICS, INC (MRKR) United States $0.013B 0.00
Ainos (AIMD) United States $0.013B 0.00
BioLineRx (BLRX) Israel $0.012B 0.00
Scienture Holdings (SCNX) United States $0.012B 0.00
Minerva Neurosciences (NERV) United States $0.010B 1.82
Talphera (TLPH) United States $0.010B 0.00
Mangoceuticals (MGRX) United States $0.010B 0.00
Kiora Pharmaceuticals (KPRX) United States $0.009B 0.00
Addex Therapeutics (ADXN) Switzerland $0.009B 0.00
Phio Pharmaceuticals (PHIO) United States $0.008B 0.00
Biomerica (BMRA) United States $0.008B 0.00
Incannex Healthcare (IXHL) Australia $0.008B 0.00
Carisma Therapeutics (CARM) United States $0.008B 0.00
Traws Pharma (TRAW) United States $0.008B 0.00
NLS Pharmaceutics (NLSP) Switzerland $0.007B 0.00
Citius Pharmaceuticals (CTXR) United States $0.007B 0.00
Nuvilex (PMCB) United States $0.007B 0.00
Klotho Neurosciences (KLTO) United States $0.007B 0.00
XTL Biopharmaceuticals (XTLB) Israel $0.006B 0.00
Lyra Therapeutics (LYRA) United States $0.006B 0.00
Quoin Pharmaceuticals (QNRX) United States $0.006B 0.00
TransCode Therapeutics (RNAZ) United States $0.006B 0.00
Indaptus Therapeutics (INDP) United States $0.005B 0.00
Sonoma Pharmaceuticals (SNOA) United States $0.005B 0.00
Plus Therapeutics (PSTV) United States $0.005B 0.00
Aptorum Group (APM) United Kingdom $0.005B 0.00
Xenetic Biosciences (XBIO) United States $0.004B 0.00
Alaunos Therapeutics (TCRT) United States $0.004B 0.00
Clearmind Medicine (CMND) Canada $0.004B 0.00
CERo Therapeutics Holdings (CERO) United States $0.004B 0.00
PainReform (PRFX) Israel $0.004B 0.00
Aditxt (ADTX) United States $0.004B 0.00
XORTX Therapeutics (XRTX) Canada $0.003B 0.00
60 Degrees Pharmaceuticals (SXTP) United States $0.003B 0.00
InMed Pharmaceuticals (INM) Canada $0.003B 0.00
SciSparc (SPRC) Israel $0.003B 0.00
Redhill Biopharma (RDHL) Israel $0.003B 0.00
Heatwurx (PCSA) United States $0.003B 0.00
Jaguar Animal Health (JAGX) United States $0.003B 0.00
Conduit Pharmaceuticals (CDT) United States $0.003B 0.00
Qualigen Therapeutics (QLGN) United States $0.003B 0.00
Galmed Pharmaceuticals (GLMD) Israel $0.002B 0.00
TNF Pharmaceuticals (TNFA) United States $0.002B 0.00
Shuttle Pharmaceuticals Holdings (SHPH) United States $0.002B 0.00
Salarius Pharmaceuticals (SLRX) United States $0.002B 0.00
Universe Pharmaceuticals INC (UPC) China $0.000B 0.00
4D Pharma (LBPS) United Kingdom $0.000B 0.00
Patheon (PTHN) Netherlands $0.000B 0.00
RVL Pharmaceuticals (RVLP) United States $0.000B 0.00
Silence Therapeutics (SLN) United Kingdom $0.000B 0.00